Search results for " FDA"
showing 4 items of 4 documents
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
2016
BACKGROUND The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate. METHODS In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in t…
Kinase Inhibitors in Multitargeted Cancer Therapy
2017
The old-fashioned anticancer approaches, aiming in arresting cancer cell proliferation interfering with non-specific targets (e.g. DNA), have been replaced, in the last decades, by more specific target oriented ones. Nonetheless, single-target approaches have not always led to optimal outcomes because, for its complexity, cancer needs to be tackled at various levels by modulation of several targets. Although at present, combinations of individual single-target drugs represent the most clinically practiced therapeutic approaches, the modulation of multiple proteins by a single drug, in accordance with the polypharmacological strategy, has become more and more appealing. In the perspective of…
Depth-based methods for clustering of functional data.
2017
The problem of detecting clusters is a common issue in the analysis of functional data and some interesting intuitions from approaches relied on depth measures can be considered for construction of basic tools for clustering of curves. Motivated by recent contributions on the problem clustering and alignment of functional data, we also consider the problem of aligning a set of curves when classification procedures are implemented. The variability among curves can be interpreted in terms of two components, phase and amplitude; phase variability, or misalignment, can be eliminated by aligning the curves, according to a similarity index and a warping function. Some approaches address the misal…
Empirical Orthogonal Function and Functional Data Analysis Procedures to Impute Long Gaps in Environmental Data
2016
Air pollution data sets are usually spatio-temporal multivariate data related to time series of different pollutants recorded by a monitoring network. To improve the estimate of functional data when missing values, and mainly long gaps, are present in the original data set, some procedures are here proposed considering jointly Functional Data Analysis and Empirical Orthogonal Function approaches. In order to compare and validate the proposed procedures, a simulation plan is carried out and some performance indicators are computed. The obtained results show that one of the proposed procedures works better than the others, providing a better reconstruction especially in presence of long gaps.